ATM Signaling Network
| PAG Title | ATM Signaling Network |
| PAG ID | WIG001821 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | Ataxia telangiectasia mutated (ATM) is a serine/threonine-specific protein kinase that is recruited and activated by DNA double-strand breaks (DSBs). It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, and H2AX are tumor suppressors. |
| Species | Homo sapiens |
| nCoCo Score | 2,858 |
| Base PAG ID | WIG001821 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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